Although its function in glucose metabolism has been well documented 6—12the role of FoxO1 in hepatic lipid metabolism remains an area of active investigation 61012— Adenovirus-mediated overexpression of the constitutively nuclear FoxO1 mutant FoxO1ADA increases triglycerides in the mouse liver but decreases triglycerides in the circulation In line with this observation, deletion of FoxO1 in the liver of systemic insulin receptor IR knock-out mice reverses the development of hepatic steatosis However, liver-specific FoxO1 knock-out mice manifest increased secretion of VLDL triglycerides in the streptozotocin-induced diabetic state
The steady state levels of mRNA and protein were assessed in the crushed or permanently transected rat sciatic nerve at 0, 1, 4, 7, 10, 12, 14, 21, and 35 days after injury.
The mRNA and protein steady state levels of the myelin specific genes, P0 and the MBPs, decreased to low yet detectable levels during Wallerian degeneration and returned to normal levels with subsequent axonal regeneration. The steady state level of P2 protein also followed a similar pattern of expression.
The steady state level of MAG mRNA decreased to undetectable levels by 4 days of injury in the permanently transected nerve. After crush injury, re-expression of MAG to levels comparable to those of normal nerves preceded that of P2 by 2 days and that of P0 and the MBPs by 3 weeks during axonal regeneration and remyelination.
These results support the proposed roles for MAG in the formation of initial Schwann cell-axonal contact required for myelin assembly, for P2 in fatty acid transportant during myelination, and for P0 and the MBPs in the maintenance of the integrity and compactness of the myelin sheath.
In addition, these results indicate that the expression of the myelin specific genes, P0 and MBP, is constitutive and that the level of myelin specific mRNAs is modulated by axonal contact and myelin assembly.The control of innate immune responses through activation of the nuclear transcription factor NF-κB is essential for the elimination of invading microbial pathogens.
We showed that the bacterial N -(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulation of NF-κB functions in activated mammalian cells. The consequence is .
Modulation of host gene expression and innate immunity by viruses [electronic resource] / edited by Peter Palese. DNA methylation is an epigenetic mechanism used by cells to control gene expression. These findings prompted the researchers to explore whether DNA methylation status of PPARα target genes, which is modulated and established in a PPARα-dependent manner in early life, persists into adulthood.
Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain By Eloise Hudry, Jonathan Dashkoff, Alysson D.
Roe, Shuko Takeda, Robert M. Koffie, Tadafumi Hashimoto, Maria Scheel, Tara Spires-Jones, Michal Arbel-Ornath, Rebecca Betensky, Beverly L.
Davidson, Bradley T. Modulation of Fgf21 gene in early-life ameliorates adulthood diet-induced obesity Date: March 9, Source: Tokyo Medical and Dental University Summary: The importance of good nutrition in the early development of children has .
Modulation and Regulation of Gene Expression by CpG ODN In vivo Regulatory Networks Underlying CpG-Dependent Gene Expression In vivo Temporal Pattern of Gene Upregulation Mediated by TLR9 Engagement..